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pentobarbital will lessen the level or effect of isradipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unidentified.pentobarbital will reduce the extent or effect of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.pentobarbital will lessen the level or impact